Immunforsvar og betennelse

Ingen andre antibiotika angriper dette proteinet. Det betyr at det er et nytt «target». Derfor finnes det heller ikke bakterier som er resistente mot disse peptidene.

In our efforts to develop oncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were highly effective against both drug-resistant and drug-sensitive cancer cells and with lower toxicity toward normal cells.

The oncolytic peptide LTX-315, which has been de novo designed based on structure-activity relationship studies of host defense peptides, has the ability to kill human cancer cells and induce specific anticancer immune response when injected locally into tumors.

Highly antimicrobial active arginine- and tryptophan-rich peptides were synthesized ranging in size from 11 to five amino acid residues in order to elucidate the main structural requirement for such short antimicrobial peptides.

The interference with such a fundamental cell structure is assumed to hamper resistance development. In the present review we discuss antimicrobial peptides isolated from marine invertebrates, emphasizing the isolation and activity of these natural antimicrobial compounds.

Marine invertebrates are a rich source for the discovery of novel antimicrobial peptides, compounds regarded as important defense compounds.

Microbial co-cultivations remain relevant in the search for new antibacterial compounds and may be the most effective way to detect bioactive metabolites that may prove necessary to combat rising antimicrobial resistance.